The Prostanoid Receptors: Molecular Approaches to Drug Development. Reproduction physiology and prostanoids.
نویسندگان
چکیده
منابع مشابه
Prostanoids and prostanoid receptors in signal transduction.
Prostanoids are arachidonic acid metabolites and are generally accepted to play pivotal functions in amongst others inflammation, platelet aggregation, and vasoconstriction/relaxation. Inhibition of their production with, for instance, aspirin has been used for over a century to combat a large variety of pathophysiological processes, with great clinical success. Hence, the cellular changes indu...
متن کاملPhysiology and pathophysiology of prostanoid receptors
Prostanoids, consisting of prostaglandins (PGs) and thromboxanes (TXs), are oxygenated products of C20 unsaturated fatty acids. They include PGD2, PGE2, PGF2 α , PGI2, and TXA2. Given that aspirin-like nonsteroidal anti-inflammatory drugs exert their actions by suppressing prostanoid production, prostanoids have been implicated in processes inhibited by these drugs, including inflammation, feve...
متن کاملProstanoid receptors: ontogeny and implications in vascular physiology.
Prostanoids exert significant effects on circulatory beds. They play a role in the response of the vasculature to adjustments in perfusion pressure and oxygen and carbon dioxide tension, and they mediate the actions of numerous factors. The role of prostanoids in governing circulation of the perinate is suggested to surpass that in the adult. Prostanoids are abundantly generated in the perinate...
متن کاملReciprocal regulation of human platelet function by endogenous prostanoids and through multiple prostanoid receptors.
Platelets are permanently exposed to a variety of prostanoids formed by blood cells or the vessel wall. The two major prostanoids, prostacyclin and thromboxane act through well established pathways mediated by their respective G-protein coupled receptors inhibiting or promoting platelet aggregation accordingly. Yet the role of other prostanoids and prostanoid receptors for platelet function reg...
متن کاملReproduction – fetal development, placenta and maternal physiology
Rudolf Cardinal, 22/24 Nov 1998 Implantation and the decidual response • Implantation in humans and some other species is invasive – the uterine surface epithelium is breached and the underlying stroma is invaded. (In yet other species, the epithelium remains intact with the fetal and maternal epithelia in close contact.) • The blastocyst makes a signal (unknown) which induces a stromal respons...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Folia Pharmacologica Japonica
سال: 2001
ISSN: 0015-5691,1347-8397
DOI: 10.1254/fpj.117.267